Distorted NCI Test Summaries

The National Cancer Institute (NCI) has made a web page to summarize its testing of Cancell. On this web page, NCI made an amazingly deceptive statement about the cancer cell kill rate of Cancell and never mentions the tumor weight reductions. Tumor weight data takes up 8 of the 14 columns on the NCI test data sheets.  Why didn't they mention tumor weight loss?

The text below presents and responds to the distorted NCI summary statements regarding cancer cell kill rate and tumor weight reductions produced by Cancell.

Cell Kill Rate Statement by NCI

You can find the following amazingly deceptive statement in the "Laboratory/Animal/Preclinical Studies" section of the new NCI Cancell/Entelev page:

"Based on these results and calculations of the maximum amount of Cancell/Entelev that would be available in the bloodstream of a patient after taking the recommended dose of a marketed brand, Cancell/Entelev may exhibit some inhibitory effect on the growth of some cancer cells, but it would not be expected to inhibit their growth completely or to kill them. It should also be noted that Cancell/Entelev was completely devoid of cancer cell killing activity in 37% of the cell lines tested-even at the highest concentration, which is roughly 275 times higher than the theoretical concentration that can be achieved in the blood of Cancell/Entelev consumers."

There are a number of very good reasons why Cancell did not appear to kill cancer cells during this test. They are explained the the following paragraphs.

Cancer Cells Under Cancell Must First Digest Themselves Before Dying

Cancell does not directly kill cancer cells; it causes cancer cells to digest themselves (to lyse). While the cancer cells are digesting themselves, they are still alive. They must be alive or they could not continue to digest themselves. The NCI test is run for a short period of time designed for fast acting chemo-like drugs. If the test was run for a slow acting cancer treatment like Cancell, by the end of the test, all the cells that had been digesting themselves would be dead. As it was, the tumor cells had dramatically reduced their weight by slowly digesting themselves, but they were mostly still alive at the end of the test.

Concentration Is Not An Issue

It is the goal of Cancell to move the respiration process of cancer cells down past a certain point on the oxidation reduction ladder as explained by James Sheridan. Once this point is crossed, a cancer cell will start to digest itself. It does not matter how much further you try and push by increasing the concentration of Cancell, the rate of digestion does not increase. Also, the number of cells that undergo the desired reduction does not increase with an increase in Cancell concentration.

Weight Loss Ignored?

It is unbelievable that the people testing Cancell did not question their low cancer cell kill ratios in light of the fact that tumor weight was being drastically reduced in every one of the 60 test tumors (see Table 2, three screens below). How could the test evaluators ignore such dramatic tumor weight reduction? Tumor weight data takes up most of the space on the NCI data sheets, eight of the 14 columns are used to measure tumor weight loss.

Pharmacology Not Interesting?

When a new cancer treatment comes out, I would imagine that every doctor's first question is "How does it work?" The method of Cancell's operation was never held secret. How could the testers be so uninterested in the pharmacology of Cancell that they did not know that Cancell causes tumor cells to digest themselves? How could they not know such a basic aspect of the treatment they were testing?

NCI Tumor Weight Reductions Test Data

The data in Table 2 below was taken from three sets of test results developed by the National Cancer Institute (NCI). In these tests:

• NCI measures anti-cancer activity by percentage growth and the number of cells killed. Negative percentage growth is encouraging. Killing cellsis also encouraging, but the test was not run long enough for Cancell to cause the cancer cells to completely digest themselves (lyse) and actuallyregister as being killed.

• NCI uses five different concentrations of the compound under test for each tumor type.

• For simplicity, Table 2 shows the best percentage growth result from the five concentrations. This puts toxic compounds like Chemo in a much better light than they deserve because some concentrations would be too strong to withstand while Cancell is non-toxic.

New as of 1 Oct 2001 - Downloadable Test Results in PDF.

Table 2 Notes

NT = not tested. The tumor types used for testing changed from time to time. Since the compounds in Table 2 were tested during different years some tumor types tested with one compound were not tested with another compound.

The last three columns contain the tumor mass change percentage for the compounds under test.

Compounds under test - Perillyl alcohol - know to be inactive against tumors, Toxal - the "gold standard" chemo, Cancell - the champion of the tests.

Mass change percentage - the percentage change in weight obtained when comparing the tumor weight before and after the test period.

Test period - the time during which the tumors were exposed to the compound under test.

Colors

Red - mass reduction greater than 95%

Blue - mass reduction greater than 80%

The colored entries are also in italics if you print this page on a black and while printer.

Just scan each of the last three columns looking for blue and red -- color in a column shows a strong anti-cancer result.

Perillyl and Taxol were tested on two other cancer panels that Cancell was not tested against so these panels were not included in the table.

NCI Test Sheets

Below the exampletest sheet and its explanation, are links to high and low resolution graphicsof the test sheets for:

• Perilly alcohol, 641066-T/2,which was judged inactive by NCI

• Taxol, 125973-L/19,a popular chemotherapeutic agentNCI judged to be active

• Cancell, 637907-L/1

Example Test Sheet
Click this example sheet to see the full sheet.
Use your back button to continue reading the explanation of the columns.

There are 14 columns on the NCI test sheets. From left to right:

Column 1 lists the tumor type tested.

Columns 4 to 7 define the concentrations of the compound under test. This helps determine correct dosage for follow-on testing.

Columns 8 to 11 contain the actual results expressed in percentage growth of the tumors. A reduction in mass is indicated by a negative number and indicates anti-cancer activity. There are four numbers for each tumor type meaning that four tumors of that type were tested at four different concentrations.

Columns 11 to 14 contain the actual results expressed in number of cells killed. The NCI summary of this parameter and my rebuttal can be found above in the "Cell Kill Rate Statement by NCI" section.

New as of 1 Oct 2001 - Downloadable Test Results in PDF.

Low Resolution

These links allow you to see the whole sheet on your browser and print them out (sometimes)in fax quality. If you want higher resolution, scroll down the page to the"High Resolution" section.

Perilly alcohol low res

Taxol low res

Cancell low res

Printing Instructions for Low or High Resolution

1. After the page appears that contains the datasheet, right click the image. A menu drops down.

2. Select Save Image As. A dialog box appears for selecting the directory on your hard drive to store the graphic file.

3. Select a directory you will remember and click Save or OK. The graphic file is saved to your hard disk.

4. Use Windows Explorer or some other file manager to click on the graphic file. If it opens in a browser window, try printing it. If it opens in a graphics program you can resize it before you print it. Try using 8 X 10.6 inches.

A graphic program may be needed to print your graphic file. You can get an evaluation copy of PaintShop from numerous web sites.

High Resolution

These links are very high resolution so you can only view a small portion of the datasheet at a time.

Perilly alcohol high res

Taxol high res

Cancell high res

If you can't print the above .gif files you can contact NCI at:

When contacting NCI you should request the in-vitro test results for 637907-L/1 tested in Nov of 1990 and any tests results of an active compound and an inactive compound for comparison. Also ask them to include the common names for the compounds whose results you receive. If you give them a fax number they will fax them to you. Each set of test results is about seven pages long and includes the all important Data Review Checklist which contains their decision to proceed with or abandon further investigation. Recently, people requesting Cancell test data have been given a run around. Apparently, NCI is trying to cover their tracks.

Cancell Home Page | Excerpts from World Without Cancer | How Cancell Works