| A proposed refinement of the mitochondrial free radical theory of aging | 12/08/2004 | |
| A proposed refinement of the mitochondrial free radical theory of aging | 12/08/2004 | |
| Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer | 12/08/2004 | It is increasingly proposed that reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a key role in human cancer development, especially as evidence is growing that antioxidants may prevent or delay the onset of some types of cancer. |
| Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer | 12/08/2004 | |
| Denham Harman, MD, Ph.D. | 12/08/2004 | |
| Denham Harman, MD, Ph.D. | 12/08/2004 | Few medical researchers are fortunate enough to find an important biological process that is linked to a wide range of human diseases. With the discovery of the significance of free-radical damage in biological systems, Denham Harman initiated an avalanche of discoveries about myriad disease processes and therapies to alleviate them.
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| Father of the Free Radical Theory of Aging Looks Ahead | 12/08/2004 | |
| Father of the Free Radical Theory of Aging Looks Ahead | 12/08/2004 | Aging is the accumulation of changes that increase the risk of death. These changes can be attributed to such factors as development, genetic defects, disease, the environment and the inborn aging process. Today, support for the theory that aging is caused fundamentally by free radical reactions in the body is extensive.
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| Free Radical | 12/08/2004 | The term "free radical" is fairly well known, but the word "Radical" is often used to mean the same thing as "free radical." When the word "radical" is connected to a symbol for some element, such as hydrogen, the term would be "H-Radical" meaning that it was a "hydrogen free radical."
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| Free Radical | 12/08/2004 | |
| Free Radical #2 | 12/08/2004 | One way to think of a free radical is that it is looking for a mate. Remember that the hydrogen free radical has only one electron in its outer ring. |
| Free Radical #2 | 12/08/2004 | |
| Free Radical #3 | 12/08/2004 | Notice definition number 2. If you "oxidize" an "atom" you "increase" the charge by "removing electrons." This the definition to use for Dr. Asai's purposes. Notice also, the misleading meaning of definition #1:
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| Free Radical #3 | 12/08/2004 | |
| Free Radicals | 12/08/2004 | |
| Free Radicals | 12/08/2004 | |
| Free Radicals and Neuroprotection | 12/08/2004 | |
| Free Radicals and Neuroprotection | 12/08/2004 | Free radical formation and cellular damage is greatly accelerated in situations of oxidative stress such as tissue injury, viral and bacterial infections and also accompanies phagocytosis autoimmune disorders and degenerative diseases by yet unknown mechanisms. Some neoplasms may occur as a result of oxidative or free radical damage. |
| How Does A Cell Use Sugar Instead of Oxygen For Energy? | 12/08/2004 | |
| How Does A Cell Use Sugar Instead of Oxygen For Energy? | 12/08/2004 | |
| Matrix Metalloproteinase | 12/08/2004 | Cancers are cells that grow and divide without normal regulation. They can be local or metastasize. Until recently, the only treatment of metastatic tumors was cytotoxic chemotherapy. A complex process is involved in the development of metastases: invasion, intravasation of primary tumor cells, circulation, extravasation, seeding, and proliferation at distant sites. |
| Matrix Metalloproteinase | 12/08/2004 | |
| Metabolic Typing, Oxygen and Anti-Oxidants | 12/08/2004 | The body has 2 kinds of metabolism when it comes to oxygen: aerobic (with oxygen) and anaerobic (without oxygen). While it is true that certain infections, cancers and other adversities thrive in an anaerobic environment, it is not true that anaerobic is “bad” and that aerobic is “good” or that everyone should do whatever possible to increase oxygen and aerobic metabolism in the body. |
| Metabolic Typing, Oxygen and Anti-Oxidants | 12/08/2004 | |
| Oxidative Theory of Cancer | 12/08/2004 | |
| Oxidative Theory of Cancer | 12/08/2004 | Each cell has the biochemical machinery for behaving as a cancer cell. Each cancer cell has the capacity for "normalizing" its behavior. What is the evidence for my viewpoint? |
| The FULL Cycle Of Cancer -- Normal Cell To Metastasis | 12/08/2004 | |
| The FULL Cycle Of Cancer -- Normal Cell To Metastasis | 12/08/2004 | Karl Note: I consider the article below to be an extremely "important" piece of data because it is written by scientists who are part of the research effort to improve on conventional cancer treatment -- that which I call the "slash/burn/poison" technology. |
| The FULL Cycle Of Cancer -- To `Metastasis -- Part II | 12/08/2004 | There has been intense interest in learning more about the specific nature of these proteases, since inhibiting them would go a long way toward preventing metastasis. Much of the focus has been on the family of proteases called matrix metalloproteinases (MMPs). |
| The FULL Cycle Of Cancer -- To `Metastasis -- Part II | 12/08/2004 | |
| The Membrane Theory | 12/08/2004 | Harman also proposed that the aging process is now the major risk factor for disease and death after age 28 in developed countries, and takes the 'politically incorrect' view that aging may also be viewed as a disease, implying that the diseases of aging may be considered to be symptoms of this underlying 'super disease' (Table I). (5) These free radical related diseases include cancer, atherosclerosis, amyloidosis, age-related immune deficiency, senile dementia, and hypertension. |
| The Membrane Theory | 12/08/2004 | |
| Water, The chemistry of life. | 12/08/2004 | Whenever we attempt to determine whether there is life as we know it on Mars or other planets, scientists first seek to establish whether or not water is present. Why? Because life on earth totally depends on water.
A High percentage of living things, both plant and animal are found in water. All life on earth is thought to have arisen from water. The bodies of all living organisms are composed largely of water. About 70 to 90 percent of all organic matter is water.
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| Water, The chemistry of life. | 12/08/2004 | |
| What Is Cancer -- An Overview | 12/08/2004 | Cancer is a word that refers to approximately 150 diseases that exhibit two characteristics in common: (1) an uncontrolled growth of cells and (2) the ability to invade and damage normal tissues either locally or at distant sites in the body. |
| What Is Cancer -- An Overview | 12/08/2004 | |
