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The Aging
Healthfully Virtual Library -
The Works of Majid Ali, M.D.
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Oxidative Theory
of Cancer
From The Book
RDA: Rats, Drugs and Assumptions
PART 4
AN OXYPHILE TURNS INTO AN OXYPHOBE
Each cell
has the biochemical machinery for behaving as a cancer cell. Each cancer
cell has the capacity for "normalizing" its behavior. What is the evidence
for my viewpoint?
A cancer cell is an
aerobic healthy cell before it becomes a predominantly anaerobic cell---as a
result of oxidative injury to its DNA, DNA repair enzymes and possibly some
regulatory proteins according to my theory presented here. How does it
happen?
In my Book The Canary and Chronic Fatigue, I
describe the evolution on aerobic (oxygen-utilizing) microbes from earlier
anaerobic (nonoxygen-utilizing) life forms.
The later aerobic microbes
retain the DNA necessary for anaerobic existence of their predecessors.
Thus, all an oxygen-utilizing cell requires to switch into a nonoxygen-utilizing
mode is a reversion to its primitive mode. Does this ever happen? Of course
it does! A common example of this phenomenon is when a colon cancer cells
reverts back to its earlier form, recalls a forgotten memory and begins to
make CEA---carcinoembyonic antigen material used to diagnose colon and other
cancers.
Another common example
of this phenomenon is when well-differentiated cancers lose their
differentiation and become de-differentiated. Ontogeny follow phylogeny is
the common scientific expression for such regression.
What turns a healthy "oxyphile"
cell into a oxyphobe? Oxidative injury. I consider this a logical and
inescapable conclusion drawn from a vast body of experimental and clinical
data and my strong intuitive sense about it.
Cancer is Reversible
Why do cancer cells develop a strong negative
charge? This simple question arose in my mind sometime ago. Evidently it can
happen in two ways:
1) Cancer cell
membranes accumulate negatively charged electrons in response to changes in
their environment; and
2) They do so in
response to metabolic changes taking place within them, such as speeded-up
anaerobic metabolism that increases acidotic stress and excessive production
of hydrogen peroxide.
Since free-floating
cancer cells metastasize freely---multiply and flourish---in otherwise
healthy tissues, it seems probable that the strong negative charge develops
on the surface of the cancer cell in order to provide a counterbalance to
the strong positive charge within it.
Next came the
expected question: If reversal of a strong negative surface charge results
in tumor regression, it is not clear evidence that the cell innards might
also respond to changes in the surface charge?
In other words, cancer
is a reversible phenomenon.
This provides
additional challenge to the prevailing dogma that cancer is caused by
mutated genes, and that genes, once mutated, cannot become "unmutated."
Slowly the concept
evolved in my mind that cancer represents abnormal growth and replication
behavior of the cell in response to changes in its electromagnetic and
biochemical micro-environment---and that such abnormal growth behavior is
reversible if the micro-environmental factors that caused it to become
errant are removed.
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